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Transcription-dependent degradation controls the stability of the SREBP family of transcription factors
Cholesterol metabolism is tightly controlled by members of the sterol regulatory element-binding protein (SREBP) family of transcription factors. Here we demonstrate that the ubiquitination and degradation of SREBPs depend on their transcriptional activity. Mutations in the transactivation or DNA-bi...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC283507/ https://ncbi.nlm.nih.gov/pubmed/14615581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2335135100 |
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