Mutational Derivatives of PhiC31 Integrase With Increased Efficiency and Specificity

ϕC31 integrase is a sequence-specific phage recombinase that can recombine two short DNA sequences called attB and attP. The enzyme can also promote genomic integration of plasmids carrying attB into native mammalian sequences having partial identity to attP. To increase the efficiency of integratio...

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Bibliographic Details
Main Authors: Keravala, Annahita, Lee, Solomon, Thyagarajan, Bhaskar, Olivares, Eric C, Gabrovsky, Vanessa E, Woodard, Lauren E, Calos, Michele P
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834998/
https://ncbi.nlm.nih.gov/pubmed/19002165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.241
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