Enhanced Therapeutic Efficacy by Simultaneously Targeting Two Genetic Defects in Tumors

Targeting tumor-specific gene abnormalities has become an attractive approach in developing therapeutics to treat cancer. Overexpression of Bcl2 and mutations of p53 represent two of the most common molecular defects in tumors. In the nucleus, p53 induces cell cycle arrest, while it interacts with B...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhang, He, Wang, Haibo, Zhang, Jianjun, Qian, Guanxiang, Niu, Beibei, Fan, Xianqun, Lu, Jian, Hoffman, Andrew R., Hu, Ji-Fan, Ge, Shengfang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2008
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834989/
https://ncbi.nlm.nih.gov/pubmed/19018252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.236
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