Enhanced Therapeutic Efficacy by Simultaneously Targeting Two Genetic Defects in Tumors

Targeting tumor-specific gene abnormalities has become an attractive approach in developing therapeutics to treat cancer. Overexpression of Bcl2 and mutations of p53 represent two of the most common molecular defects in tumors. In the nucleus, p53 induces cell cycle arrest, while it interacts with B...

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Detalhes bibliográficos
Main Authors: Zhang, He, Wang, Haibo, Zhang, Jianjun, Qian, Guanxiang, Niu, Beibei, Fan, Xianqun, Lu, Jian, Hoffman, Andrew R., Hu, Ji-Fan, Ge, Shengfang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834989/
https://ncbi.nlm.nih.gov/pubmed/19018252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.236
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