Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

Secretion of tumor necrosis factor-α (TNF-α) by macrophages plays a predominant role in the development and progression of rheumatoid arthritis. We demonstrate that knockdown of TNF-α expression in systemic macrophages by intraperitoneal (i.p.) administration of chitosan/small interfering RNA (siRNA...

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Bibliographic Details
Main Authors: Howard, Kenneth A, Paludan, Søren R, Behlke, Mark A, Besenbacher, Flemming, Deleuran, Bent, Kjems, Jørgen
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834976/
https://ncbi.nlm.nih.gov/pubmed/18827803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.220
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