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An acid-sensing ion channel from shark (Squalus acanthias) mediates transient and sustained responses to protons

Acid-sensing ion channels (ASICs) are proton-gated Na(+) channels. They are implicated in synaptic transmission, detection of painful acidosis, and possibly sour taste. The typical ASIC current is a transient, completely desensitizing current that can be blocked by the diuretic amiloride. ASICs are...

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Bibliografske podrobnosti
Main Authors: Springauf, Andreas, Gründer, Stefan
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834940/
https://ncbi.nlm.nih.gov/pubmed/20064854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.182931
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