Proton-mediated Conformational Changes in an Acid-sensing Ion Channel

Acid-sensing ion channels are cation channels activated by external protons and play roles in nociception, synaptic transmission, and the physiopathology of ischemic stroke. Using luminescence resonance energy transfer (LRET), we show that upon proton binding, there is a conformational change that i...

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Bibliografiske detaljer
Main Authors: Ramaswamy, Swarna S., MacLean, David M., Gorfe, Alemayehu A., Jayaraman, Vasanthi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861639/
https://ncbi.nlm.nih.gov/pubmed/24196950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478982
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