Role of Conformational Dynamics in α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Partial Agonism

We have investigated the range of cleft closure conformational states that the agonist-binding domains of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors occupy when bound to a series of willardiine derivatives using single-molecule FRET. These studies show that the agonist...

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Main Authors: Ramaswamy, Swarna, Cooper, David, Poddar, Nitesh, MacLean, David M., Rambhadran, Anu, Taylor, J. Nick, Uhm, Heui, Landes, Christy F., Jayaraman, Vasanthi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527942/
https://ncbi.nlm.nih.gov/pubmed/23115239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371815
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