Loss of Jak2 Selectively Suppresses DC-Mediated Innate Immune Response and Protects Mice from Lethal Dose of LPS-Induced Septic Shock

Given the importance of Jak2 in cell signaling, a critical role for Jak2 in immune cells especially dendritic cells (DCs) has long been proposed. The exact function for Jak2 in DCs, however, remained poorly understood as Jak2 deficiency leads to embryonic lethality. Here we established Jak2 deficien...

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Autores principales: Zhong, Jixin, Yang, Ping, Muta, Kenjiro, Dong, Robert, Marrero, Mario, Gong, Feili, Wang, Cong-Yi
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834745/
https://ncbi.nlm.nih.gov/pubmed/20231889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009593
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