Loss of Jak2 Selectively Suppresses DC-Mediated Innate Immune Response and Protects Mice from Lethal Dose of LPS-Induced Septic Shock

Given the importance of Jak2 in cell signaling, a critical role for Jak2 in immune cells especially dendritic cells (DCs) has long been proposed. The exact function for Jak2 in DCs, however, remained poorly understood as Jak2 deficiency leads to embryonic lethality. Here we established Jak2 deficien...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhong, Jixin, Yang, Ping, Muta, Kenjiro, Dong, Robert, Marrero, Mario, Gong, Feili, Wang, Cong-Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834745/
https://ncbi.nlm.nih.gov/pubmed/20231889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009593
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados