Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome

Sepsis refers to the systemic inflammatory response syndrome caused by infection. It is a major clinical problem and cause of death for patients in intensive care units worldwide. The Fat mass and obesity-related protein (FTO) is the primary N (6)-methyladenosine demethylase. However, the role of FT...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Luo, Jiahui, Wang, Faxi, Sun, Fei, Yue, Tiantian, Zhou, Qing, Yang, Chunliang, Rong, Shanjie, Yang, Ping, Xiong, Fei, Yu, Qilin, Zhang, Shu, Wang, Cong-Yi, Li, Jinxiu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128997/
https://ncbi.nlm.nih.gov/pubmed/34017338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.663295
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