Small molecule activators of TRPML3

We conducted a high-throughput screen for small molecule activators of the TRPML3 ion channel which, when mutated, causes deafness and pigmentation defects. Cheminformatics analyses of the 53 identified and confirmed compounds revealed nine different chemical scaffolds and 20 singletons. We found th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Grimm, Christian, Jörs, Simone, Saldanha, S. Adrian, Obukhov, Alexander G., Pan, Bifeng, Oshima, Kazuo, Cuajungco, Math P., Chase, Peter, Hodder, Peter, Heller, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834294/
https://ncbi.nlm.nih.gov/pubmed/20189104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.12.016
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