Small molecule activators of TRPML3

We conducted a high-throughput screen for small molecule activators of the TRPML3 ion channel which, when mutated, causes deafness and pigmentation defects. Cheminformatics analyses of the 53 identified and confirmed compounds revealed nine different chemical scaffolds and 20 singletons. We found th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Grimm, Christian, Jörs, Simone, Saldanha, S. Adrian, Obukhov, Alexander G., Pan, Bifeng, Oshima, Kazuo, Cuajungco, Math P., Chase, Peter, Hodder, Peter, Heller, Stefan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834294/
https://ncbi.nlm.nih.gov/pubmed/20189104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.12.016
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