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Small molecule activators of TRPML3

We conducted a high-throughput screen for small molecule activators of the TRPML3 ion channel which, when mutated, causes deafness and pigmentation defects. Cheminformatics analyses of the 53 identified and confirmed compounds revealed nine different chemical scaffolds and 20 singletons. We found th...

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Main Authors: Grimm, Christian, Jörs, Simone, Saldanha, S. Adrian, Obukhov, Alexander G., Pan, Bifeng, Oshima, Kazuo, Cuajungco, Math P., Chase, Peter, Hodder, Peter, Heller, Stefan
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834294/
https://ncbi.nlm.nih.gov/pubmed/20189104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.12.016
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