The active metabolite of leflunomide, A77-1726, increases proliferation of human synovial fibroblasts in presence of IL-1β

Míreanna Comhchosúla

• The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes
  le: Palmer, Gaby, et al.
  Foilsithe: (2004)
• Effects of leflunomide on interleukin-1 receptor antagonist (IL-1Ra) synthesis in chondrocytes and synovial fibroblasts
  le: Palmer, G, et al.
  Foilsithe: (2003)
• Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1β stimulated rheumatoid synovial fibroblasts
  le: MIGITA, K, et al.
  Foilsithe: (2004)
• The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
  le: Kirsch, Bernhard M, et al.
  Foilsithe: (2005)
• Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide.
  le: Bruneau, J M, et al.
  Foilsithe: (1998)