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Design, Synthesis and Evaluation of Indole Compounds as Novel Inhibitors targeting Gp41

A series of indole ring containing compounds were designed based on the structure of the gp41 complex in the region of the hydrophobic pocket. These compounds were synthesized using a Suzuki Coupling reaction, and evaluated using a fluorescence binding assay and cell-cell fusion assay. The observed...

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書誌詳細
主要な著者: Zhou, Guangyan, Wu, Dong, Hermel, Evan, Balogh, Edina, Gochin, Miriam
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833348/
https://ncbi.nlm.nih.gov/pubmed/20153190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.111
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