Stimuli-responsive star polyethylene glycol conjugates for improved intracellular delivery of N-acetyl cysteine in neuroinflammation

N-Acetyl cysteine (NAC) is an important drug currently under clinical trials for the treatment of neuroinflammation in maternal-fetal applications. The free sulfhydryl groups in NAC lead to high plasma protein binding, resulting in low bioavailability. Preparation and activity of conjugates of NAC w...

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Hlavní autoři: Navath, Raghavendra S., Wang, Bing, Kannan, Sujatha, Romero, Roberto, Kannan, Rangaramanujam M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833236/
https://ncbi.nlm.nih.gov/pubmed/19896998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2009.10.035
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