Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2

We report the first crystal structure of a 1:2 hormone·receptor complex that involves prolactin (PRL) as the ligand, at 3.8-Å resolution. Stable ternary complexes were obtained by generating affinity-matured PRL variants harboring an N-terminal tail from ovine placental lactogen, a closely related P...

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Detalhes bibliográficos
Main Authors: Broutin, Isabelle, Jomain, Jean-Baptiste, Tallet, Estelle, van Agthoven, Jan, Raynal, Bertrand, Hoos, Sylviane, Kragelund, Birthe B., Kelly, Paul A., Ducruix, Arnaud, England, Patrick, Goffin, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832991/
https://ncbi.nlm.nih.gov/pubmed/20053995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089128
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