mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

The mammalian target of rapamycin (mTOR) Ser/Thr kinase signals in at least two multiprotein complexes distinguished by their different partners and sensitivities to rapamycin. Acute rapamycin inhibits signaling by mTOR complex 1 (mTORC1) but not mTOR complex 2 (mTORC2), which both promote cell grow...

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Autores principales: Soliman, Ghada A., Acosta-Jaquez, Hugo A., Dunlop, Elaine A., Ekim, Bilgen, Maj, Nicole E., Tee, Andrew R., Fingar, Diane C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832937/
https://ncbi.nlm.nih.gov/pubmed/20022946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096222
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