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Modulation of polyglutamine conformations and dimer formation by the N-terminus of Huntingtin

Polyglutamine expansions within different proteins are associated with nine different neurodegenerative diseases. There is growing interest in understanding the roles of flanking sequences from disease-relevant proteins on the intrinsic conformational and aggregation properties of polyglutamine. We...

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Bibliografische gegevens
Hoofdauteurs: Williamson, Tim E., Vitalis, Andreas, Crick, Scott L., Pappu, Rohit V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832287/
https://ncbi.nlm.nih.gov/pubmed/20026071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.12.017
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