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Thermodynamics of β-Sheet Formation in Polyglutamine

The role of β-sheets in the early stages of protein aggregation, specifically amyloid formation, remains unclear. Interpretations of kinetic data have led to a specific model for the role of β-sheets in polyglutamine aggregation. According to this model, monomeric polyglutamine, which is intrinsical...

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Bibliografiske detaljer
Main Authors: Vitalis, Andreas, Lyle, Nicholas, Pappu, Rohit V.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711364/
https://ncbi.nlm.nih.gov/pubmed/19580768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.05.003
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