Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

The use of the effective antineoplastic agent cisplatin is limited by its serious side effects, such as oto- and nephrotoxicity. Ototoxicity is a problem of special importance in children, because deafness hampers their language and psychosocial development. Recently, organic cation transporters (OC...

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Main Authors: Ciarimboli, Giuliano, Deuster, Dirk, Knief, Arne, Sperling, Michael, Holtkamp, Michael, Edemir, Bayram, Pavenstädt, Hermann, Lanvers-Kaminsky, Claudia, am Zehnhoff-Dinnesen, Antoinette, Schinkel, Alfred H., Koepsell, Hermann, Jürgens, Heribert, Schlatter, Eberhard
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832140/
https://ncbi.nlm.nih.gov/pubmed/20110413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090610
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