Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2

Cis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we clearly identify the human organic cation transporter 2 (hOCT2) as the critical transporter for cis-platin nephrotoxicity in isolated human proximal tubules and offer a potential mechanism for reducing neph...

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Main Authors: Ciarimboli, Giuliano, Ludwig, Thomas, Lang, Detlef, Pavenstädt, Hermann, Koepsell, Hermann, Piechota, Hans-Jürgen, Haier, Jörg, Jaehde, Ulrich, Zisowsky, Jochen, Schlatter, Eberhard
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2005
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1613191/
https://ncbi.nlm.nih.gov/pubmed/16314463
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