DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA replication stress. Although the mechanism of CFS expression has not been fully elucidated, one known feature is a severely delayed S-phase. We used an in vitro primer extension assay to examine the progression of...

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Bibliographische Detailangaben
Hauptverfasser: Shah, Sandeep N., Opresko, Patricia L., Meng, Xiao, Lee, Marietta Y. W. T., Eckert, Kristin A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831333/
https://ncbi.nlm.nih.gov/pubmed/19969545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1131
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