Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their Saccharomyces cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid str...

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Detaylı Bibliyografya
Asıl Yazarlar: Johnson, Jay E., Cao, Kajia, Ryvkin, Paul, Wang, Li-San, Johnson, F. Brad
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2010
Konular:
Gene Regulation, Chromatin and Epigenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831322/
https://ncbi.nlm.nih.gov/pubmed/19966276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1103
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