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Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their Saccharomyces cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid str...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831322/ https://ncbi.nlm.nih.gov/pubmed/19966276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1103 |
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