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PI(3,4,5)P(3) Potentiates Phospholipase C-β Activity

Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Previously, we had shown that PLC-β1 and PLC-β3 bound immobilized PIP(3). In this study, PIP(3) was found to potentiate Ca(2+)-stimulated PLC-β activities using an in vitro reconstitution assay. LY294002, a...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Yong, Kwon, Sun Hyung, Vogel, Walter K., Filtz, Theresa M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830898/
https://ncbi.nlm.nih.gov/pubmed/19519170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10799890902729449
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