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Phospholipase C Regulation of Phosphatidylinositol 3,4,5-trisphosphate-mediated Chemotaxis

Generation of a phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P(3)] gradient within the plasma membrane is important for cell polarization and chemotaxis in many eukaryotic cells. The gradient is produced by the combined activity of phosphatidylinositol 3-kinase (PI3K) to increase PI(3,4,5)P(3)...

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Main Authors: Korthol, Arjan, King, Jason S., Keizer-Gunnink, Ineke, Harwood, Adrian J., Van Haastert, Peter J.M.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096598/
https://ncbi.nlm.nih.gov/pubmed/17898079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-05-0407
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