Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

To understand the role of mitochondrial uncoupling protein (UCP) in regulating insulin signaling and glucose homeostasis, we created transgenicDrosophila lines with targeted UCP expression in insulin producing cells (IPCs). Increased UCP activity in IPCs results in decreased steady state Ca(2+) leve...

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Detalhes bibliográficos
Main Authors: Fridell, Yih-Woei C., Hoh, Melissa, Kréneisz, Orsolya, Hosier, Suzanne, Chang, Chengyi, Scantling, Dane, Mulkey, Daniel K., Helfand, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2009
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830081/
https://ncbi.nlm.nih.gov/pubmed/20195385
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