Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

To understand the role of mitochondrial uncoupling protein (UCP) in regulating insulin signaling and glucose homeostasis, we created transgenicDrosophila lines with targeted UCP expression in insulin producing cells (IPCs). Increased UCP activity in IPCs results in decreased steady state Ca(2+) leve...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Fridell, Yih-Woei C., Hoh, Melissa, Kréneisz, Orsolya, Hosier, Suzanne, Chang, Chengyi, Scantling, Dane, Mulkey, Daniel K., Helfand, Stephen L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2009
Ämnen:
Priority Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830081/
https://ncbi.nlm.nih.gov/pubmed/20195385
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk