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Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis
ATM and p53 are critical regulators of the cellular DNA damage response, and function as potent tumor suppressors. In cells undergoing ionizing radiation, ATM is activated by double-strand DNA breaks and phosphorylates the amino terminus of p53 at serine residue 18. We have previously generated mice...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829875/ https://ncbi.nlm.nih.gov/pubmed/20145032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0324 |
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