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Loss of p53 Ser18 and Atm Results in Embryonic Lethality without Cooperation in Tumorigenesis
Phosphorylation at murine Serine 18 (human Serine 15) is a critical regulatory process for the tumor suppressor function of p53. p53Ser18 residue is a substrate for ataxia-telangiectasia mutated (ATM) and ATM-related (ATR) protein kinases. Studies of mice with a germ-line mutation that replaces Ser1...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3181255/ https://ncbi.nlm.nih.gov/pubmed/21980358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024813 |
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