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Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice

RecA/Rad51 protein family members (Rad51, Rad51b, Rad51c, Rad51d, Xrcc2, and Xrcc3) are essential for DNA repair by homologous recombination and their role in cancers has been anticipated. Here we provide the first direct evidence for a tumor suppressor function for a member of the Rad51 family. We...

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Bibliografski detalji
Glavni autori: Kuznetsov, Sergey G., Haines, Diana C., Martin, Betty K., Sharan, Shyam K.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754281/
https://ncbi.nlm.nih.gov/pubmed/19155299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3057
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