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Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis
ATM and p53 are critical regulators of the cellular DNA damage response, and function as potent tumor suppressors. In cells undergoing ionizing radiation, ATM is activated by double-strand DNA breaks and phosphorylates the amino terminus of p53 at serine residue 18. We have previously generated mice...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829875/ https://ncbi.nlm.nih.gov/pubmed/20145032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0324 |
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