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ATM promotes apoptosis and suppresses tumorigenesis in response to Myc

Overexpression of the c-myc oncogene contributes to the development of a significant number of human cancers. In response to deregulated Myc activity, the p53 tumor suppressor is activated to promote apoptosis and inhibit tumor formation. Here we demonstrate that p53 induction in response to Myc ove...

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Bibliografski detalji
Glavni autori: Pusapati, Raju V., Rounbehler, Robert J., Hong, SungKi, Powers, John T., Yan, Mingshan, Kiguchi, Kaoru, McArthur, Mark J., Wong, Paul K., Johnson, David G.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1345703/
https://ncbi.nlm.nih.gov/pubmed/16432227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507367103
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