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Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
Mouse p53 is phosphorylated at Ser18 and Ser23 after DNA damage. To determine whether these two phosphorylation events have synergistic functions in activating p53 responses, we simultaneously introduced Ser18/23 to Ala mutations into the endogenous p53 locus in mice. While partial defects in apopto...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1478190/ https://ncbi.nlm.nih.gov/pubmed/16757976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601167 |
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