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Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis
The p53 tumour suppressor is activated in response to a wide variety of genotoxic stresses, frequently via post-translational modification. Using a knock in mouse model with a Ser312 to Ala mutation, we show here that phosphorylation of p53 on Ser312 helps to prevent tumour induction by the alkylati...
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| Hoofdauteurs: | , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3813944/ https://ncbi.nlm.nih.gov/pubmed/24173284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03105 |
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