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Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315
We show here that the cell cycle-dependent DNA-binding and transcriptional activity of p53 correlates with E2F expression in human primary fibroblasts. E2F1 binds and stimulates DNA-binding, transactivation and apoptotic functions of p53 but not p63 and p73. E2F1 binds residues 347–370 of p53 and en...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1182237/ https://ncbi.nlm.nih.gov/pubmed/16037820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600735 |
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