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Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315

We show here that the cell cycle-dependent DNA-binding and transcriptional activity of p53 correlates with E2F expression in human primary fibroblasts. E2F1 binds and stimulates DNA-binding, transactivation and apoptotic functions of p53 but not p63 and p73. E2F1 binds residues 347–370 of p53 and en...

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Bibliografiske detaljer
Main Authors: Fogal, Valentina, Hsieh, Jung-Kuang, Royer, Christophe, Zhong, Shan, Lu, Xin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182237/
https://ncbi.nlm.nih.gov/pubmed/16037820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600735
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