LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

We identify the leucine-rich repeat transmembrane protein LRRTM2 as a key regulator of excitatory synapse development and function. LRRTM2 localizes to excitatory synapses in transfected hippocampal neurons, and shRNA-mediated knockdown of LRRTM2 leads to a decrease in excitatory synapses without af...

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Autors principals: de Wit, Joris, Sylwestrak, Emily, O’Sullivan, Matthew L., Otto, Stefanie, Tiglio, Katie, Savas, Jeffrey N., Yates, John R., Comoletti, Davide, Taylor, Palmer, Ghosh, Anirvan
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829666/
https://ncbi.nlm.nih.gov/pubmed/20064388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.12.019
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