Unbiased Discovery of Glypican as a Novel Receptor for LRRTM4 in Regulating Excitatory Synapse Development

Leucine-rich repeat (LRR) proteins have recently been identified as important regulators of synapse development and function, but for many LRR proteins the ligand-receptor interactions are not known. Here we identify the heparan sulfate (HS) proteoglycan glypican as a novel receptor for LRRTM4 using...

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Main Authors: de Wit, Joris, O’Sullivan, Matthew L., Savas, Jeffrey N., Condomitti, Giuseppe, Caccese, Max C., Vennekens, Kristel M., Yates, John R., Ghosh, Anirvan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003527/
https://ncbi.nlm.nih.gov/pubmed/23911103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.06.049
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