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Postsynaptic FLRT proteins are endogenous ligands for the black widow spider venom receptor Latrophilin and regulate excitatory synapse development

Latrophilins (LPHNs) are a small family of G-protein coupled receptors known to mediate the massive synaptic exocytosis caused by the black widow spider venom α-latrotoxin, but their endogenous ligands and function remain unclear. Mutations in LPHN3 are strongly associated with attention deficit hyp...

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Autors principals: O'Sullivan, Matthew L., de Wit, Joris, Savas, Jeffrey N., Comoletti, Davide, Otto-Hitt, Stefanie, Yates, John R., Ghosh, Anirvan
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326387/
https://ncbi.nlm.nih.gov/pubmed/22405201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.01.018
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