Structural and mechanistic insights into the latrophilin3 - FLRT3 complex that mediates glutamatergic synapse development

Latrophilins (LPHNs) are adhesion-like G protein coupled receptors implicated in attention-deficit/hyperactivity disorder (ADHD). Recently, LPHN3 was found to regulate excitatory synapse number through trans interactions with fibronectin leucine-rich repeat transmembrane 3 (FLRT3). By isothermal tit...

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Publicado en:Structure
Autores principales: Ranaivoson, Fanomezana M., Liu, Qun, Martini, Francesca, Bergami, Francesco, von Daake, Sventja, Li, Sheng, Lee, David, Demeler, Borries, Hendrickson, Wayne A., Comoletti, Davide
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930246/
https://ncbi.nlm.nih.gov/pubmed/26235031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.06.022
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