Evaluation of an Attenuated Vesicular Stomatitis Virus Vector Expressing Interferon-β for Use in Malignant Pleural Mesothelioma: Heterogeneity in Interferon Responsiveness Defines Potential Efficacy

Vesicular stomatitis virus (VSV) has shown promise as an oncolytic agent, although unmodified VSV can be neurotoxic. To avoid toxicity, a vector was created by introducing the interferon-β (IFN-β) gene (VSV.IFN-β). We conducted this study to determine the ability of VSV.IFN-β to lyse human cancer (m...

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Detalhes bibliográficos
Main Authors: Saloura, Vassiliki, Wang, Liang-Chuan S., Fridlender, Zvi G., Sun, Jing, Cheng, Guanjun, Kapoor, Veena, Sterman, Daniel H., Harty, Ronald N., Okumura, Atsushi, Barber, Glen N., Vile, Richard G., Federspiel, Mark J., Russell, Stephen J., Litzky, Leslie, Albelda, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829454/
https://ncbi.nlm.nih.gov/pubmed/19715403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.088
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