Evaluation of an Attenuated Vesicular Stomatitis Virus Vector Expressing Interferon-β for Use in Malignant Pleural Mesothelioma: Heterogeneity in Interferon Responsiveness Defines Potential Efficacy

Vesicular stomatitis virus (VSV) has shown promise as an oncolytic agent, although unmodified VSV can be neurotoxic. To avoid toxicity, a vector was created by introducing the interferon-β (IFN-β) gene (VSV.IFN-β). We conducted this study to determine the ability of VSV.IFN-β to lyse human cancer (m...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Saloura, Vassiliki, Wang, Liang-Chuan S., Fridlender, Zvi G., Sun, Jing, Cheng, Guanjun, Kapoor, Veena, Sterman, Daniel H., Harty, Ronald N., Okumura, Atsushi, Barber, Glen N., Vile, Richard G., Federspiel, Mark J., Russell, Stephen J., Litzky, Leslie, Albelda, Steven M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Mary Ann Liebert, Inc. 2010
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829454/
https://ncbi.nlm.nih.gov/pubmed/19715403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.088
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