Expression of Interferon-β Enhances Both Efficacy and Safety of Oncolytic Vesicular Stomatitis Virus for Therapy of Mesothelioma

Our pre-clinical and clinical trials using a replication-defective adenoviral vector expressing IFN-β have shown promising results for the treatment of malignant mesothelioma. Based on the hypotheses that a replication-competent Vesicular Stomatitis Virus (VSV) oncolytic vector would transduce more...

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Autors principals: Willmon, Candice L., Saloura, Vassiliki, Fridlender, Zvi G., Wongthida, Phonphimon, Diaz, Rosa Maria, Thompson, Jill, Kottke, Timothy, Federspiel, Mark, Barber, Glen, Albelda, Steven M., Vile, Richard G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891512/
https://ncbi.nlm.nih.gov/pubmed/19773437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1013
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