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Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

OBJECTIVE: To test the hypothesis that obesity resulting from deletion of the leptin gene or leptin receptor gene results in increased knee osteoarthritis, systemic inflammation, and altered subchondral bone morphology. METHODS: We studied leptin deficient (ob/ob) and leptin receptor deficient (db/d...

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Main Authors: Griffin, Timothy M., Huebner, Janet L., Kraus, Virginia B., Guilak, Farshid
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829313/
https://ncbi.nlm.nih.gov/pubmed/19790050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24854
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