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Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
OBJECTIVE: To test the hypothesis that obesity resulting from deletion of the leptin gene or leptin receptor gene results in increased knee osteoarthritis, systemic inflammation, and altered subchondral bone morphology. METHODS: We studied leptin deficient (ob/ob) and leptin receptor deficient (db/d...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2829313/ https://ncbi.nlm.nih.gov/pubmed/19790050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24854 |
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