Adeno-Associated Virus-Mediated Gene Transfer to Nonhuman Primate Liver Can Elicit Destructive Transgene-Specific T Cell Responses

Gene transfer to murine liver with vectors based on novel adeno-associated virus (AAV) serotypes is efficient, stable, and safe even in the setting of antigenic transgene products. We undertook a study in cynomolgus macaques to evaluate the relevance of these findings to primates. The vectors were b...

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Hlavní autoři: Gao, Guangping, Wang, Qiang, Calcedo, Roberto, Mays, Lauren, Bell, Peter, Wang, Lili, Vandenberghe, Luk H., Grant, Rebecca, Sanmiguel, Julio, Furth, Emma E., Wilson, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2009
Témata:
Scientific Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829282/
https://ncbi.nlm.nih.gov/pubmed/19441963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.060
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