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Mutant p53 Gain-of-Function in Cancer

In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding p53. Typically, the affected tumor cells accumulate excessive amounts of the mutant p53 protein. Various lines of evi...

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Détails bibliographiques
Auteurs principaux: Oren, Moshe, Rotter, Varda
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828285/
https://ncbi.nlm.nih.gov/pubmed/20182618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a001107
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