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Mutant p53 Gain-of-Function in Cancer
In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding p53. Typically, the affected tumor cells accumulate excessive amounts of the mutant p53 protein. Various lines of evi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2828285/ https://ncbi.nlm.nih.gov/pubmed/20182618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a001107 |
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